Translational Regulation of Sf1 Integrates Alternative Splicing and Hematopoietic Stem Cell Fate
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The authors investigate how mRNA isoform regulation influences the fate decisions of hematopoietic stem cells (HSCs) during their transition from quiescence to lineage commitment. They identify the splicing regulator Sf1 as a critical component of a translationally controlled splicing program that modulates HSC differentiation and DNA damage response through alternative splicing. This study highlights the intricate relationship between translational regulation, splicing, and HSC fate determination.
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