Niche-targeted therapy via YAP/TAZ activation enhances hematopoietic regeneration
Listen to this summary
The authors investigate the role of YAP/TAZ activation in enhancing hematopoietic regeneration following myeloablative stress, focusing on how these pathways can restore the bone marrow niche that supports hematopoietic stem cells (HSCs). They demonstrate that YAP/TAZ are crucial for the recovery of endothelial cells and mesenchymal stromal cells, which in turn promotes efficient hematopoietic recovery. The study suggests that pharmacological activation of YAP/TAZ could serve as a therapeutic strategy to improve hematopoietic regeneration by enhancing niche resilience.
This is one of 33,000+ journals available on OSLR. Try it free for 14 days.
Free 14-day trial. 33,000+ journals. Cancel anytime.
More from Blood
View all →Jun 25, 2026 · Blood
Galectin-1 Fuels Monocyte Hyperinflammation and Represents a Novel Therapeutic Target in Myeloproliferative Neoplasms
Jun 25, 2026 · Blood
Translational Regulation of Sf1 Integrates Alternative Splicing and Hematopoietic Stem Cell Fate
Jun 25, 2026 · Blood
NG2-ITGA4 axis regulates Rho GTPases and leukemic aggressiveness in KMT2A-r B-ALL and is targetable with natalizumab
Jun 25, 2026 · Blood
Combining Quizartinib with intensive chemotherapy in older patients with newly diagnosed AML: results of the UK NCRI AML18 Trial
Jun 24, 2026 · Blood
Direct and indirect regulation of fetal globin transcript by RNA-binding protein IGF2BP1
Jun 20, 2026 · Blood
Ibrutinib in early stage CLL: Genetic risk factors and treatment outcome in the GCLLSG CLL12 trial
More in Internal Medicine
View all →Jun 25, 2026 · The American journal of sports medicine
Association of Central Acetabular Osteophytes With Microinstability and Increased Combined Anteversion in Borderline Dysplasia Hips
Jun 24, 2026 · Journal of hepatology
Regression of liver cirrhosis
Jun 24, 2026 · Journal of addiction medicine
Medicaid Prior Authorization and Discontinuation of Buprenorphine
Jun 24, 2026 · Journal of addiction medicine
Implementation of Dyadic Care to Support Clinical, Administrative, and Service Wraparound Needs for the Opioid-Exposed Mother and Infant
Jun 24, 2026 · Critical care medicine
Ethical Implications of the Slow Code: A Systematic Review of Ethics of Slow Codes in U.S. Hospitals
Jun 24, 2026 · Lancet (London, England)
Safety, pharmacokinetics, and exploratory efficacy of the oral ghrelin receptor agonist AC01 in heart failure with reduced ejection fraction (GOAL-HF1): a randomised, double-blind, placebo-controlled, phase 1b/2a study
"Oslr has become part of my weekly routine on my day off. The clinical relevance of the summaries is outstanding — I'd rate it 9/10. Being able to consume research hands-free is a huge advantage for busy physicians."
Dr. Jennifer Thompson
Portland, OR
Stay current without falling behind
33,000+ journals. 3-minute audio summaries. Free for 14 days.
