NG2-ITGA4 axis regulates Rho GTPases and leukemic aggressiveness in KMT2A-r B-ALL and is targetable with natalizumab
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The authors investigate the role of the NG2-ITGA4 signaling axis in the aggressiveness of KMT2A-rearranged B-cell acute lymphoblastic leukemia (KMT2A-r B-ALL), a subtype associated with poor prognosis and high relapse rates. They demonstrate that NG2 promotes cell proliferation and migration through Rho GTPase activity in an ITGA4-dependent manner, and show that targeting ITGA4 with natalizumab can delay leukemia progression and enhance chemotherapy efficacy in patient-derived models. This study highlights a potential therapeutic strategy for improving outcomes in KMT2A-r B-ALL patients.
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