Retinoic acid-driven expansion of CD16hiCD177+ neutrophils mediates steroid-resistant GI-GVHD
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The authors investigate the role of a specific neutrophil subset (CD16hiCD177⁺) in the pathogenesis of steroid-resistant gastrointestinal graft-versus-host disease (SR-GI-GVHD) following allogeneic hematopoietic stem cell transplantation. They find that elevated retinoic acid levels drive the expansion and pathogenic programming of these neutrophils, which contribute to tissue damage through the release of neutrophil extracellular traps. The study suggests that targeting the retinoic acid receptor may offer a novel therapeutic approach to improve treatment outcomes for SR-GI-GVHD.
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