Direct and indirect regulation of fetal globin transcript by RNA-binding protein IGF2BP1
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The authors investigate the role of the RNA-binding protein IGF2BP1 in the regulation of fetal globin transcripts, specifically HBG1/2, and its relationship with the transcriptional repressor BCL11A. They reveal that IGF2BP1 not only indirectly regulates HBG1/2 by suppressing BCL11A but also directly binds to HBG1/2 transcripts to enhance their translation through m6A modifications. This study enhances the understanding of the molecular mechanisms underlying hemoglobin switching during development.
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