June 22, 2026 · JAMA internal medicine · DOI: 10.1001/jamainternmed.2026.2036

Multilevel Stewardship Intervention for Use of Anticoagulation-Antiplatelet Therapy

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The authors aimed to evaluate the effectiveness of a multilevel antithrombotic stewardship initiative in reducing unnecessary antiplatelet use among patients prescribed direct oral anticoagulants (DOACs). The study found that the combined interventions, which included educational outreach and modifications to electronic health records, led to a significant reduction in antiplatelet prescriptions, particularly in patients with stable coronary artery disease. This highlights the potential of scalable stewardship approaches to improve medication safety and adherence to evidence-based practices.

Jacob E Kurlander, David Parra, Von Moore, Rob Holleman, Jennifer Burns, Amanda M Midboe, Brittani Garlick, Ariel Domlyn, Linda Chia, Geoffrey D Barnes, H Myra Kim, Jeremy B Sussman

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