June 15, 2026 · JAMA internal medicine · DOI: 10.1001/jamainternmed.2026.1936

Estimated Effectiveness of 2024-2025 COVID-19 Vaccines in Adults

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The authors aimed to assess the effectiveness of the 2024-2025 COVID-19 vaccines in preventing medically attended COVID-19 cases among adults in the U.S. Their findings indicate that vaccination was associated with a 26% to 41% reduction in the likelihood of COVID-19-related emergency department visits, hospitalizations, and critical illness, with effectiveness waning over time since vaccination. This underscores the importance of COVID-19 vaccinations for both immunocompetent and immunocompromised adults.

Ryan E Wiegand, Amanda B Payne, Josephine Mak, Sean Chickery, Sarah E Reese, Nicola P Klein, Shaun J Grannis, Toan C Ong, Elizabeth A K Rowley, Malini DeSilva, Kristin Dascomb, Stephanie A Irving, Ousseny Zerbo, John R Hansen, Lawrence Block, Karen B Jacobson, Brian E Dixon, Colin M Rogerson, Thomas J Duszynski, William F Fadel, Michelle A Barron, David Mayer, Catia Chavez, Duck-Hye Yang, Sarah W Ball, Charlene E McEvoy, Omobosola O Akinsete, Tamara Sheffield, Daniel Bride, Julie Arndorfer, Joshua Van Otterloo, Allison L Naleway, Karthik Natarajan, Morgan Najdowski, Allison Avrich Ciesla, Amber Kautz, Jennifer DeCuir, Ruth Link-Gelles

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