June 11, 2026 · Critical care medicine · DOI: 10.1097/CCM.0000000000007210

Correlation Between Quantitative Pupillometry and Other Markers for Neuroprognostication of Comatose Patients After Cardiac Arrest: A Bicentric Study

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The authors aimed to investigate the correlation between quantitative pupillometry (qPLR) and other neuroprognostic markers in comatose patients following cardiac arrest. They found that low qPLR values were strongly associated with poor outcomes and correlated with clinical features, EEG findings, and serum neuron-specific enolase levels, while high qPLR values had limited predictive power for good outcomes. Overall, the study suggests that while qPLR is a useful prognostic tool, its performance does not surpass that of qualitative pupillary light reflex assessments.

Sarah Benghanem, Jan Novy, Alain Cariou, Nawfel Ben-Hamouda, Andréa O Rossetti

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