Pulse Pressure Variation During Passive Leg Raising to Assess Preload Responsiveness: Influence of Inspiratory Effort During Pressure Support Ventilation

The authors aimed to determine whether changes in pulse pressure variation (PPV) and pulse pressure (PP) during passive leg raising (PLR) can effectively assess preload responsiveness in critically ill patients undergoing pressure support ventilation (PSV). Their findings indicate that PLR-induced changes in PPV are associated with preload responsiveness, particularly in patients with lower inspiratory effort, suggesting that this method can predict cardiac output response to fluid administration without the need for direct measurements.