International Validation of Temperature-Trajectory Sepsis Subphenotypes With Longitudinal Immune and Coagulation Patterns and Its Implications for Immunoglobulin Therapy
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This study aimed to validate a temperature-trajectory model of sepsis in a Chinese cohort and characterize the immune and coagulation profiles associated with distinct sepsis subphenotypes. The findings confirmed that the hypothermic (HT) subphenotype had the highest mortality and exhibited significant immune dysfunction and coagulopathy. Additionally, the study revealed that responses to immunoglobulin therapy varied across subphenotypes, highlighting the potential for precision medicine in treating sepsis.
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