Comparison of Intensive Versus Conventional Glycemic Control Targets: An Updated Systematic Review and Meta-Analysis of the 2024 Society of Critical Care Medicine Guidelines on Glycemic Control for Critically Ill Adults
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The authors aimed to evaluate the efficacy and safety of intensive versus conventional blood glucose targets in critically ill adults receiving insulin infusions. Their systematic review and meta-analysis of 45 randomized controlled trials found no significant differences in hospital or ICU mortality between the two approaches, but intensive targets were linked to lower ICU length of stay and fewer infections, albeit with a significantly higher risk of severe hypoglycemia. The findings suggest that while intensive targets may improve certain morbidity outcomes, they should not be routinely adopted due to safety concerns regarding hypoglycemia.
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