Estrogen protects female mice with chronic kidney disease from fibroblast growth factor 23-induced left ventricular hypertrophy
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The authors investigate how estrogen influences cardiac responses to fibroblast growth factor 23 (FGF23) in female mice with chronic kidney disease (CKD), particularly in relation to left ventricular hypertrophy (LVH). Their findings reveal that estrogen protects female mice from FGF23-induced LVH, highlighting sex-specific differences in cardiovascular risk and the potential molecular mechanisms involved. This study underscores the cardioprotective role of estrogen in females with CKD and identifies common signaling pathways between FGF23 and estrogen in the heart.
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