A MEF2C transcription factor network regulates proliferation of glomerular endothelial cells in diabetic kidney disease
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The authors aimed to investigate the regulatory mechanisms of endothelial and mesangial cells in diabetic kidney disease (DKD) by identifying transcription factor networks that influence cell proliferation and injury. They discovered that the MEF2C, MEF2A, and TRPS1 transcription factor network plays a crucial role in maintaining the balance between healthy and injured endothelial cell states, with dysregulation linked to disease progression. Furthermore, treatment with sodium glucose transporter-2 inhibitors (SGLT2i) was found to reverse the adverse effects of this network in DKD.
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