Reversal of advanced diabetic kidney disease in mice treated with a monoclonal anti-VEGFR1 antibody
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The authors aimed to investigate the therapeutic potential of targeting VEGF-A and its receptors in advanced diabetic kidney disease (DKD) using various mouse models. They found that while blocking VEGF-A and VEGFR2 worsened kidney injury, selective inhibition of VEGFR1 significantly improved kidney function, reduced albuminuria, and even reversed established kidney damage, suggesting that VEGFR1 blockade could be a promising strategy for treating advanced DKD.
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