The calcimimetic etelcalcetide restores cardiac function in chronic hyperphosphatemia via calcium sensing receptor-cAMP activation
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The authors investigate the cardioprotective effects of the calcimimetic etelcalcetide (Etel) in the context of chronic hyperphosphatemia and its underlying mechanisms. They demonstrate that Etel restores cardiac function and contractility impaired by high phosphate levels through the activation of the calcium sensing receptor (CaSR) and associated signaling pathways. The findings suggest that Etel mitigates cardiac dysfunction and fibrosis despite persistent hyperphosphatemia by normalizing hormonal levels and enhancing calcium signaling.
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