April 24, 2026 · The American journal of medicine · DOI: 10.1016/j.amjmed.2026.04.022

Electronic Alert-Based Computerized Decision Support for Detection of Chronic Kidney Disease in Type 2 Diabetes Mellitus: The CKD-DETECT Randomized Trial

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The authors aimed to evaluate the effectiveness of an electronic alert-based computerized decision support (CDS) system in increasing the screening for chronic kidney disease (CKD) through urine albumin-to-creatinine ratio (UACR) testing in patients with type 2 diabetes. The CKD-DETECT trial found that the alert significantly increased UACR testing rates compared to a control group, although it did not result in a notable increase in new CKD diagnoses or referrals to nephrologists. Overall, the study suggests that alert-based CDS can enhance early detection of elevated albuminuria in this patient population.

Samuel Z Goldhaber, Sina Rashedi, Mariana Pfeferman, Hannah Leyva, Bassil Bacare, Romain Chopard, Emily S Robinson, Zhou Lan, Behnood Bikdeli, Gregory Piazza, CKD-DETECT investigators

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