Extended-Release vs Sublingual Buprenorphine in Pregnancy Through 12 Months Post Partum: A Randomized Clinical Trial
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This randomized clinical trial aimed to evaluate the effectiveness and safety of extended-release buprenorphine compared to sublingual buprenorphine for treating opioid use disorder in pregnant individuals through 12 months postpartum. The results indicated that extended-release buprenorphine was associated with higher illicit opioid abstinence rates during pregnancy and fewer serious adverse events, while postpartum abstinence rates were similar between the two groups. Overall, the findings support the use of weekly extended-release buprenorphine as a viable treatment option for opioid use disorder in pregnancy.
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