Holding vs Continuing GLP-1/GIP Agonists Before Upper Endoscopy: The OCULUS Randomized Clinical Trial
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The authors aimed to determine whether holding or continuing GLP-1 and GIP agonists before elective upper endoscopy affects the risk of clinically significant residual gastric volume (RGV). The study found that continuing these medications significantly increased the risk of clinically significant RGV compared to holding one dose, leading to the conclusion that holding the medication may be advisable prior to such procedures. Additionally, the use of clear liquids the day before the procedure appeared to mitigate this risk.
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