March 25, 2026 · Gastroenterology · DOI: 10.1053/j.gastro.2026.03.005

From Autoimmunity to Intestinal Tissue Damage: Insights From Potential Celiac Disease as a Paradigm of Disease Progression

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The authors investigate the transition from immune tolerance to autoimmunity in celiac disease (CeD), using potential celiac disease (PCD) as a model to understand disease progression. They aim to identify the immunological characteristics of PCD and the factors influencing its progression to active CeD, highlighting the need for reliable markers and preventive strategies. The study underscores the clinical implications of PCD in managing CeD and preventing organ-specific autoimmunity.

Roberta Mandile, Valentina Discepolo, Renata Auricchio, Riccardo Troncone

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