Ganglioside-Mediated Neural-Acinar Crosstalk Facilitates Pancreatic Carcinogenesis via Metaplastic Niche Remodeling
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The authors investigate the interactions between acinar-to-ductal metaplasia (ADM) and neural remodeling in the context of pancreatic ductal adenocarcinoma (PDAC) initiation and progression. They identify ganglioside metabolites, particularly GM3, as key mediators of this bidirectional crosstalk, revealing that neuronal-ADM interactions and glycosphingolipid metabolism could serve as potential therapeutic targets for early intervention in PDAC development.
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