Sickle cell disease
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This Seminar aims to provide a comprehensive update on sickle cell disease, focusing on its complex pathophysiology and the spectrum of acute and chronic complications it causes. The authors review recent advancements in treatment options, including hydroxyurea, transfusion therapy, and gene therapies, while also addressing implementation strategies in low-resource settings and ongoing challenges in managing various disease variants. Ultimately, the paper seeks to enhance understanding and improve care for individuals affected by this genetic disorder.
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