March 17, 2026 · The New England journal of medicine · DOI: 10.1056/NEJMoa2516043

Prehospital Whole Blood in Traumatic Hemorrhage - a Randomized Controlled Trial

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The authors aimed to evaluate the effectiveness and safety of prehospital whole-blood transfusion compared to standard care in patients with major traumatic hemorrhage. In a randomized controlled trial involving 616 participants, they found no significant difference in the primary outcome of death or massive transfusion within 24 hours between the whole-blood group and the standard-care group. Overall, the study concluded that prehospital whole-blood transfusion did not provide a clinical advantage over standard care in this context.

Jason E Smith, Rebecca Cardigan, Emily Sanderson, Laura Silsby, Claire Rourke, Ed B G Barnard, Peter Basham, Grazia Antonacci, Richard Charlewood, Nikki Dallas, Jane Davies, Elizabeth Goodwin, Annie Hawton, Cara Hudson, Joanne Lucas, Katie Keen, Richard M Lyon, Brodie Nolan, Gavin D Perkins, Viona Rundell, Laura Smith, Simon J Stanworth, Anne Weaver, Tom Woolley, Laura Green, SWiFT Trial Group

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