March 24, 2026 · Human reproduction (Oxford, England) · DOI: 10.1093/humrep/deag035

Human stem cell-based embryo models: innovation, ethics, and policy

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The authors aim to establish a foundational framework for research, technological development, and regulation in the emerging field of stem cell-based embryo models (SCBEMs), which are designed to mimic early human development. They seek to address the potential applications of SCBEMs in understanding embryo development and addressing health challenges, while also highlighting the ethical and legal implications that arise from this innovative research. The paper serves as a consensus document reflecting the views of a group of researchers, providing guidance for future work in this area.

Alfonso Martinez Arias, Nicolas Rivron, Shahragim Tajbakhsh, Josephine Johnston, Cantas Alev, Laure Bally-Cuif, Elvan Böke, Tommaso Cavazza, Emma Cave, David Cyranoski, Laurent David, Miguel A Esteban, Jianping Fu, Niels Geijsen, Nienke de Graeff, Jacob H Hanna, Nick Hopwood, Maneesha S Inamdar, Fredrik Lanner, Brigitte Leeners, Zhen Liu, Maitre Jean Leon, Gabriella Minchiotti, Naomi Moris, Megan Munsie, Kathy K Niakan, Olivier Pourquie, Vincent Pasque, Martin Pera, Yaojin Peng, Sophie Petropoulos, Sharad Ramanathan, Janet Rossant, Peter Rugg-Gunn, Mitinori Saitou, Karen Sermon, Jose Silva, Thorold Theunissen, Margherita Turco, John Wallingford, Hongmei Wang, Aryeh Warmflash, Jun Wu, Leqian Yu

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