Heat exposure during susceptible windows of spermatogenesis and sperm epigenetic age
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The authors investigate whether preconception exposure to outdoor heat stress during spermatogenesis affects sperm epigenetic age in men undergoing infertility treatment. They find that increased exposure to high wet bulb temperatures during critical stages of spermatogenesis is associated with accelerated sperm epigenetic age, suggesting that heat stress may negatively impact men's reproductive health. The study highlights the potential implications of environmental temperature on sperm DNA methylation and fertility outcomes.
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