March 23, 2026 · Human reproduction (Oxford, England) · DOI: 10.1093/humrep/deag039

Ovarian and reproductive hormone characteristics and risk of cycle cancellation in immediate versus postponed modified natural cycle frozen embryo transfer (mNC-FET) cycles

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This study investigates whether ovarian and reproductive hormone characteristics, as well as the risk of cycle cancellation, differ between immediate and postponed modified natural cycle frozen embryo transfer (mNC-FET) cycles. The findings indicate significant differences in ovarian morphology, hormone levels, and follicular phase length between the two approaches, with a higher but not statistically significant cancellation rate in immediate cycles. These results raise concerns about the clinical feasibility of immediate FET treatment following ovarian stimulation.

Sara Bergenheim, Amalie Somuncu Johansen, Clara Colombo, Marte Saupstad, Tine Vrist Dam, Jeanette Wulff Bogstad, Nina la Cour Freiesleben, Lisbeth Prætorius, Ida Behrendt-Møller, Birgitte Oxlund-Mariegaard, Bugge Nøhr, Merete Husth, Negjyp Sopa, Ellen Løkkegaard, Anja Pinborg, Kristine Løssl

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