How big is the time window for cell-free fetal DNA testing after pregnancy loss and which factors are associated with a successful result?

The authors investigate the decline of cell-free fetal DNA (cffDNA) following early pregnancy loss and the factors influencing its detectability. They find that cffDNA levels can remain detectable for up to three days post-tissue passage, with higher β-hCG levels correlating with increased odds of obtaining a conclusive test result. These findings suggest a need for refined cffDNA diagnostics to improve reproductive care and decision-making after pregnancy loss.