Angiography-derived fractional flow reserve versus coronary angiography to guide coronary artery bypass grafting in patients undergoing surgical valve procedures with concomitant coronary artery disease in China (FAVOR IV-QVAS): a multicentre, triple-blind, randomised trial

The study aimed to determine whether a physiologically guided strategy using angiography-derived fractional flow reserve (FFR) could improve clinical outcomes compared to the traditional anatomically guided approach for coronary artery bypass grafting (CABG) in patients undergoing surgical valve procedures with concomitant coronary artery disease. Results showed that the FFR-guided CABG significantly reduced the incidence of adverse perioperative outcomes and long-term complications compared to the standard method, suggesting that physiological assessment may enhance surgical decision-making in this patient population.