March 21, 2026 · Lancet (London, England) · DOI: 10.1016/S0140-6736(25)02637-6

Prevention of urinary stones with hydration: a randomised clinical trial of an adherence intervention

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This study aimed to evaluate the effectiveness of a multicomponent behavioral intervention designed to increase fluid intake in reducing symptomatic urinary stone recurrence compared to standard care. The results indicated that while the intervention modestly increased urine volume, it did not significantly reduce the rate of recurrent stone events over a two-year follow-up period. Overall, the findings suggest that enhancing fluid intake through behavioral strategies may not be sufficient to prevent urinary stones in recurrent stone formers.

Alana C Desai, Naim M Maalouf, Jonathan D Harper, Sri Sivalingam, John C Lieske, H Henry Lai, Peter P Reese, Hunter Wessells, Hongqiu Yang, Hussein R Al-Khalidi, Ziya Kirkali, Gregory E Tasian, Charles D Scales, Urinary Stone Disease Network Investigators

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