March 21, 2026 · Lancet (London, England) · DOI: 10.1016/S0140-6736(26)00031-0

Survival outcome of VATS compared with open lobectomy for lung cancer: an individual patient data meta-analysis of randomised trials

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The authors aimed to determine whether video-assisted thoracoscopic surgery (VATS) for pulmonary lobectomy in early-stage lung cancer offers equivalent oncological outcomes compared to open lobectomy, specifically focusing on overall and disease-free survival. Their individual patient data meta-analysis of three randomized trials involving 1,185 patients found that VATS significantly improved overall survival by 21% without compromising disease-free survival. These findings suggest that VATS should be prioritized as the preferred surgical approach for eligible patients.

Rosie A Harris, Jacie Jiaqi Law, Long Hao, Dongrong Situ, Finn Amundsen Dittberner, Morten Bendixen, Peter B Licht, Chris A Rogers, Eric Lim

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