September 17, 2026 · The American journal of medicine · DOI: 10.1016/j.amjmed.2026.09.014

Lipid deposition as a common feature of pneumonias of different etiologies

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The authors investigate the role of lipid metabolism in pneumonia, examining lipid deposition in lungs affected by both COVID-19 and non-COVID-19 pneumonias compared to non-pneumonic controls. Their findings reveal significant lipid accumulation in pneumonic tissues, particularly in inflamed areas, and suggest alterations in lipid biosynthesis and storage pathways, indicating that these metabolic changes may serve as potential diagnostic and therapeutic targets across various pneumonia types.

Daria M Potashnikova, Anna V Tvorogova, Tatiana N Sotnikova, Alexey A Komissarov, Kirill N Zhuravlev, Aleena A Saidova, Valerya O Makarova, Eugene A Arifulin, Tatiana V Lipina, Olesya M Shirokova, Eugene S Melnikov, Tatiana A Rodina, Anna A Valyaeva, Anastasia A Zharikova, George O Zayratyants, Oleg V Zayratyants, Oleg V Kokorev, Anna Tkachev, Elena A Stekolshchikova, Philipp E Khaitovich, Eugene V Sheval, Leonid B Margolis, Elena J Vasilieva

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