September 19, 2026 · Chest · DOI: 10.1016/j.chest.2026.09.006

Mixed Mucus Plug-Emphysema Subtype and Acute Exacerbation in Chronic Obstructive Pulmonary Disease

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The authors aimed to investigate the prognostic value of quantitative computed tomography-derived mucus plugs and emphysema in predicting acute exacerbations in patients with chronic obstructive pulmonary disease (COPD). Their findings revealed that higher mucus plug scores and the presence of emphysema significantly increased the risk of acute exacerbations, highlighting the importance of these metrics for personalized risk stratification and targeted prevention in COPD management.

Yang Li, Yuxia Wang, Min Zhang, Guoxuan Wang, Jia Cui, Ziqing Zhang, Xiaoyan Wang, Xingxia Yang, Yanfei Guo

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