Intensive Chemotherapy and Tyrosine Kinase Inhibitor in Patients with De Novo BCR::ABL1+ Acute Myeloid Leukemia
Listen to this summary
The authors aimed to evaluate the impact of adding a tyrosine kinase inhibitor (TKI) to intensive chemotherapy (IC) on the outcomes of patients with de novo BCR::ABL1+ acute myeloid leukemia (AML). Their analysis of 212 patients revealed that the combination of IC and TKI significantly improved complete remission rates and overall survival compared to IC alone, suggesting that this approach should be considered the standard of care and prompting a reevaluation of the classification of this condition as adverse-risk.
This is one of 33,000+ journals available on OSLR. Try it free for 14 days.
Free 14-day trial. 33,000+ journals. Cancel anytime.
More from Blood
View all →Sep 17, 2026 · Blood
IDH3 regulates citrate homeostasis to control metabolic fitness and venetoclax resistance of AML stem cells
Sep 17, 2026 · Blood
A single-cell atlas of large B cell lymphomas reveals distinct malignant archetypes predictive of clinical outcomes
Sep 11, 2026 · Blood
Neutrophil-dependent interferonopathy contributes to joint damage in hemophilia
Sep 11, 2026 · Blood
Recombinant ADAMTS13 in congenital thrombotic thrombocytopenic purpura: final analysis from a randomized phase 3 trial
Sep 9, 2026 · Blood
The stress-sensing MARCH5 axis governs blood cancer apoptotic resilience via tractable protein-protein interactions
Sep 9, 2026 · Blood
Rare Hematopoietic Stem Cells resilient to infection-induced stress sense yet withstand inflammation
More in Internal Medicine
View all →Sep 19, 2026 · Chest
Non-Cystic Fibrosis Bronchiectasis in the United States: Prevalence Trends in a Large Electronic Health Record Population, 2015-2025
Sep 19, 2026 · Chest
Thoracentesis with pleural fluid cytology versus thoracoscopy with pleural biopsy for the diagnosis of malignant pleural effusion: a cost-effectiveness study
Sep 19, 2026 · Chest
Impact of pre-ICU balanced crystalloids versus saline on mortality in sepsis: a propensity score-matched multicenter cohort study
Sep 19, 2026 · Chest
Delivering Bronchiectasis and NTM Care in Safety-Net Health Systems: A Practical Framework for Implementation
Sep 19, 2026 · The American journal of medicine
Why Exercise Does Not Work Equally Well for Everyone: Life-Course Conditions and the Limits of Precision Medicine
Sep 19, 2026 · Chest
Mixed Mucus Plug-Emphysema Subtype and Acute Exacerbation in Chronic Obstructive Pulmonary Disease
"Oslr has become part of my weekly routine on my day off. The clinical relevance of the summaries is outstanding — I'd rate it 9/10. Being able to consume research hands-free is a huge advantage for busy physicians."
Dr. Jennifer Thompson
Portland, OR
Stay current without falling behind
33,000+ journals. 3-minute audio summaries. Free for 14 days.
