Impact of pre-ICU balanced crystalloids versus saline on mortality in sepsis: a propensity score-matched multicenter cohort study

The authors aimed to determine the association between the type of crystalloid administered before ICU admission and clinical outcomes in patients with sepsis. Their multicenter cohort study found that the use of balanced crystalloids, compared to saline, was linked to significantly lower 30-day mortality rates and reduced need for renal replacement therapy, suggesting that balanced crystalloids may be a superior choice for initial fluid resuscitation in sepsis.