September 19, 2026 · Chest · DOI: 10.1016/j.chest.2026.08.050

Multicomponent Pulmonary Rehabilitation for Prolonged Mechanical Ventilation in Patients Aged 80 Years or Older: A Randomized Controlled Trial

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This randomized controlled trial investigates whether a multicomponent pulmonary rehabilitation program can enhance successful weaning from prolonged mechanical ventilation in patients aged 80 years or older. The results indicate that the rehabilitation program significantly increased the weaning success rate (45.3% vs. 12.0%) and improved various physiological outcomes without increasing the risk of deep vein thrombosis or mortality. Overall, the study suggests that such rehabilitation can lead to better recovery in this vulnerable population.

Tingting Liu, Ting Kou, Ge Wei, Hongyun Zhang, Gaoqiang Li, Huiru Hou, Bing Liu, Jing Zhao

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