A single-cell atlas of large B cell lymphomas reveals distinct malignant archetypes predictive of clinical outcomes
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The authors aimed to investigate the cellular and molecular heterogeneity of large B cell lymphomas (LBCLs) to better understand treatment responses. Through single-cell RNA sequencing and analysis of tumor biopsies, they identified five distinct transcriptional archetypes of malignant B cells, with a specific archetype linked to poor clinical outcomes. This research offers a new framework for patient stratification and potential precision therapies in LBCL treatment.
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