Overactive Bladder as a Bioenergetic Disorder: A Sex-Convergent Mitochondrial-Oxidative Framework

The authors investigate whether the diverse associations of overactive bladder (OAB) symptoms in aging individuals can be organized within a sex-convergent mitochondrial-oxidative framework, distinguishing OAB from related conditions. They find evidence suggesting that mitochondrial-oxidative injury plays a role in various models of bladder dysfunction, but highlight the need for more direct comparative studies between sexes and further validation of their proposed framework. Ultimately, they propose that mitochondrial-oxidative dysfunction may contribute to OAB, but caution against viewing it as a universal cause without additional research.