Neurourology and urodynamics
Audio Summaries

Urodynamic and Anamnestic Predictors for Individual Dose Adjustment of Intravesical Oxybutynin in Neurogenic Detrusor Overactivity: Results From the UPSIDE Study

Jun 23, 2026

The UPSIDE study aimed to identify urodynamic and anamnestic predictors for achieving a therapeutically satisfactory dose (TSD) of intravesical oxybutynin (IVO) in patients with neurogenic detrusor overactivity (NDO). The study found that older age and reduced estimated glomerular filtration rate (eGFR) were significant predictors for TSD, and IVO treatment led to notable improvements in urodynamic parameters, continence, quality of life, and reduced urinary tract infections, with high adherence and no serious adverse events reported.

Urodynamic Voiding Patterns in Multiple Sclerosis

Jun 23, 2026

This study aimed to characterize urodynamic voiding patterns in patients with multiple sclerosis (PwMS) and evaluate the effectiveness of existing indices for diagnosing bladder obstruction and contractility. The findings revealed that abnormal voiding patterns, particularly sphincter dysfunction, are prevalent among PwMS, but the diagnostic indices assessed showed low to moderate agreement with the clinical diagnoses of detrusor underactivity and obstruction. Thus, the authors suggest that current indices may not be suitable for this specific neurogenic population.

Differences in Urodynamic Findings of Robot-Assisted Radical Prostatectomy Before and 2 Years After Surgery

Jun 22, 2026

This study aimed to evaluate changes in bladder function and lower urinary tract symptoms through urodynamic assessments before and two years after robot-assisted radical prostatectomy (RARP) for prostate cancer. The findings indicated significant improvements in urinary symptoms and urodynamic parameters post-surgery; however, a notable decline in the bladder contractility index (BCI) was observed, particularly among older patients, suggesting that age may influence postoperative detrusor function deterioration.

Long-Term Functional Outcomes and Complications of Advance™/AdVance Xp™ Male Suburethral Slings in the Management of Post-Prostatectomy Incontinence: Multicentric Prospective Ten-Year Follow-Up Study

Jun 19, 2026

This study aims to evaluate the long-term functional outcomes and complications associated with the AdVance™/AdVance XP™ male suburethral slings in treating post-prostatectomy urinary incontinence over a ten-year period. The results indicate that while initial continence rates are promising, with 67.8% of patients considered cured at three months, a notable percentage (28.81%) experienced a loss of continence during follow-up, primarily due to stress urinary incontinence recurrence. Overall, the findings suggest that these sling implants provide acceptable long-term continence rates, particularly in patients with mild to moderate incontinence who have not undergone prior pelvic treatments.

Urinary Biomarkers and Response to Treatment in Overactive Bladder (OAB): A Systematic Review and Meta-Analysis

Jun 19, 2026

The authors aimed to systematically review and meta-analyze the relationship between urinary biomarkers, particularly nerve growth factor (NGF), and treatment response in adults with overactive bladder (OAB). Their findings indicate that while urinary NGF levels decrease with treatment and correlate with symptom score improvements, the overall evidence on the utility of urinary biomarkers in OAB remains heterogeneous and limited. This suggests that urinary biomarkers may be beneficial for monitoring treatment response in cases where traditional symptom questionnaires are unreliable.

Are Age and Voided Volume Sufficient to Predict Detrusor Underactivity in Women? An External Validation Study

Jun 19, 2026

The authors aimed to externally validate a non-invasive prediction model that uses age and voided volume to predict detrusor underactivity (DU) in women. Their study, involving 450 women, found that the model demonstrated poor discrimination and calibration, indicating it is not reliable for clinical screening of DU. Consequently, the results highlight the necessity for continued invasive testing to accurately diagnose this condition.

Unequal Utilization of Overactive Bladder Treatment: The Role of Socioeconomic and Insurance Disparities

Jun 18, 2026

The authors aimed to investigate how neighborhood-level socioeconomic disadvantage (SED) and insurance type affect treatment patterns for overactive bladder (OAB). Their study found that patients from disadvantaged areas were more likely to receive anticholinergic medications but less likely to be prescribed β3-agonists, while insurance status significantly influenced access to procedural treatments, with disparities observed particularly among Medicare and Black patients. Overall, the findings highlight the impact of socioeconomic and insurance disparities on the management of OAB.

Beyond Joint Hypermobility: Investigating Bladder Dysfunction in Hypermobile Ehlers-Danlos Syndrome

Jun 18, 2026

This study investigates the prevalence and characteristics of lower urinary tract symptoms (LUTS) in patients with hypermobile Ehlers-Danlos Syndrome (hEDS) to understand the underlying mechanisms of bladder dysfunction in this population. The authors found that while LUTS are common among hEDS patients, the issues appear to stem from pelvic floor and neurologic dysfunction rather than intrinsic bladder pathology. Their findings suggest a need for a pelvic floor-focused approach in the evaluation and management of LUTS associated with hEDS.

Adaptive Pudendal Nerve Stimulation: A Pilot Study on Safety, Technical Feasibility, and Clinical Effect

Jun 18, 2026

This pilot study aimed to evaluate the safety, technical feasibility, and clinical outcomes of a new adaptive pudendal nerve stimulation device in women with treatment-refractory urinary incontinence. The results indicated that the device was safe and technically feasible, with significant reductions in incontinence episodes and improvements in quality of life reported by patients at the six-month follow-up. Additionally, the adaptive stimulation feature was utilized by 70% of participants, further enhancing therapeutic outcomes.

A Novel Template for Intravesical Botulinum Toxin Injection in Patients With Idiopathic Overactive Bladder: A Cohort Study

Jun 16, 2026

This study investigates the efficacy and safety of a novel 10-point injection template for intravesical botulinum toxin A compared to the traditional 20-point template in patients with idiopathic overactive bladder (OAB) symptoms. The results indicate that the new template significantly improves symptoms of urgency, frequency, and incontinence, while demonstrating a similar safety profile to the traditional method. Overall, the novel template offers a more effective and practical approach for treating OAB in patients unresponsive to oral medications.