May 8, 2026 · Neurourology and urodynamics · DOI: 10.1002/nau.70303

Effect of Intravesical Administration of Steroid Enemas on an Experimental Autoimmune Interstitial Cystitis-Like Mouse Model

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The authors investigate the potential of intravesical steroid enemas as a treatment for interstitial cystitis/bladder pain syndrome (IC/BPS) using an experimental autoimmune interstitial cystitis (EAIC) mouse model. They compare the effects of steroid enemas to traditional dimethyl sulfoxide (DMSO) treatment, finding that steroid enemas provide superior anti-inflammatory benefits and improved bladder function without causing tissue damage or adverse effects. This study suggests that steroid enemas could be a practical and patient-friendly therapeutic option for IC/BPS, warranting further research.

Kimio Sugaya, Saori Nishijima, Katsumi Kadekawa, Katsuhiro Ashitomi, Seiji Matsumoto

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