September 10, 2026 · JAMA · DOI: 10.1001/jama.2026.15455

Rheumatoid Arthritis in Adults: A Review

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The authors review the current understanding and management of rheumatoid arthritis (RA), a chronic autoimmune disease that leads to joint destruction and disability. They emphasize the importance of early diagnosis and initiation of treatment with disease-modifying antirheumatic drugs (DMARDs), particularly methotrexate, to achieve significant improvement in disease activity. For patients who do not reach remission with first-line therapies, the addition of biological DMARDs or Janus kinase (JAK) inhibitors can enhance remission rates to approximately 80%.

Josef S Smolen, Andreas Kerschbaumer, Daniel Aletaha, William H Robinson

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