September 10, 2026 · JAMA · DOI: 10.1001/jama.2026.16557

Loberamisal for Acute Ischemic Stroke: The LAIS Randomized Clinical Trial

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The LAIS trial aimed to evaluate the efficacy and safety of intravenous loberamisal in improving functional outcomes for patients with acute ischemic stroke treated within 48 hours of symptom onset. The results indicated that loberamisal significantly increased the proportion of patients achieving favorable functional outcomes at 90 days compared to placebo, suggesting its potential as a neuroprotective therapy. However, further research is necessary to confirm these findings and assess their applicability to a wider patient population.

Shuya Li, Baoyu Feng, Dandan He, Xuechun Wang, Hao Li, Shuhong Xu, Hong-Qiu Gu, Xiaohua Xiao, Dan Deng, Xiaoli Wang, Aihong Guo, Hongguo Dai, Zixiao Li, Yilong Wang, Xingquan Zhao, Liping Liu, Yongjun Wang, LAIS investigators

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