September 6, 2026 · Journal of minimally invasive gynecology · DOI: 10.1016/j.jmig.2026.08.019

Clinical outcomes of Vaginal Natural Orifice Transluminal Endoscopic Surgery (VNOTES) in Gynecology: A Comprehensive Systematic Review and Meta-Analysis

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The authors aimed to evaluate the clinical outcomes of vaginal natural orifice transluminal endoscopic surgery (vNOTES) compared to conventional minimally invasive surgery (MIS) for benign gynecologic procedures. Their systematic review and meta-analysis of 33 studies involving over 4,000 patients found that vNOTES was associated with shorter operative times, reduced postoperative pain, fewer complications, and shorter hospital stays, suggesting it is an effective alternative to conventional MIS. However, the authors note that further prospective studies are needed to refine patient selection and indications for vNOTES.

Giorgia Dinoi, Sara Mastrovito, Vincenzo Tarantino, Camilla Riccetti, Davide Arrigo, Giancarlo Paradisi, Antonella Carcagni, Diana Giannarelli, Anna Fagotti, Francesco Fanfani, Giovanni Panico

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