Uterus-Preserving Cold-Knife Adenomyomectomy within a Three-Stage Treatment Strategy for Severe Diffuse Adenomyosis and Its effect on IVF/ICSI and Perinatal Outcomes

The authors aimed to evaluate the impact of a three-stage treatment strategy, including cold-knife adenomyomectomy, on IVF/ICSI and perinatal outcomes in women with severe diffuse adenomyosis. The study found that this approach significantly reduced uterine size and miscarriage risk, while achieving favorable clinical pregnancy and live birth rates, although it also noted a concerning incidence of uterine ruptures during delivery. The findings suggest that this fertility-sparing technique may optimize reproductive outcomes, but further research is needed to confirm these results in larger populations.