August 3, 2026 · American journal of ophthalmology · DOI: 10.1016/j.ajo.2026.07.051

Glaucoma and Neurodegenerative Disease Risk: A 10-Year Assessment of Real-World Global Data

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The authors aimed to assess the 10-year risk trajectories of newly diagnosed neurodegenerative diseases among glaucoma patients, analyzing data across age-stratified cohorts and clinical subtypes. Their findings indicate that glaucoma is associated with increased risks for Alzheimer's disease, vascular dementia, and mild cognitive impairment, with variations in risk based on the age of onset and specific glaucoma subtype. However, the study highlights that these associations are observational and do not establish causal relationships.

Man Sze Wong, Joshua Wang, Yi-Hsin Lin, Chao-Wei Wu, Hsin-Yi Chen, Kuo-Cheng Lu

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