July 31, 2026 · Lancet (London, England) · DOI: 10.1016/S0140-6736(26)01288-2

Multivessel coronary artery bypass grafting via small thoracotomy versus sternotomy (MIST): an investigator-initiated, international, open-label, randomised controlled trial

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The authors aimed to compare patient-reported recovery and clinical outcomes between minimally invasive coronary artery bypass grafting (MICS CABG) via small thoracotomy and traditional sternotomy CABG in patients with multivessel coronary artery disease. The study found that MICS CABG significantly improved physical recovery at one month post-surgery without compromising safety through 12 months, suggesting its potential benefit for appropriately selected patients.

Marc Ruel, Sathyaki Nambala, Ming Hao Guo, Alexander Verevkin, Prem Rabindranauth, Keita Kikuchi, Piroze M Davierwala, Massimo Lemma, Menaka Ponnambalam, Azmat Sheikh, Alice Black, Michael A Borger, Richard P Whitlock, Yan Zhang, George A Wells

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