American journal of ophthalmology
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Incidence of De Novo Glaucoma and Ocular Hypertension After DMEK vs DSAEK: A Systematic Review and Meta-Analysis

Sep 22, 2026

The authors aimed to estimate the incidence of de novo glaucoma and ocular hypertension (OHT) in glaucoma-naïve adult eyes undergoing Descemet membrane endothelial keratoplasty (DMEK) compared to Descemet stripping automated endothelial keratoplasty (DSAEK). Their systematic review and meta-analysis of 33 studies revealed that the pooled incidence rates were significantly lower for DMEK (3% for glaucoma and 9% for OHT) compared to DSAEK (11% for glaucoma and 34% for OHT), although the certainty of these findings was low to very low due to variability in definitions and confounding factors. The authors concluded that while DMEK appears to be associated with lower rates of these complications, further research with standardized definitions and protocols is necessary to clarify the impact of surgical technique.

Incidence, Prevalence, and Clinical Associations of Non-Infectious Pediatric Uveitis in the United States: A TriNetX Database Study

Sep 19, 2026

The authors aimed to characterize the incidence, prevalence, demographics, and clinical associations of non-infectious pediatric uveitis in the United States using the TriNetX database. They found that from 2016 to 2025, the annual incidence and prevalence of pediatric uveitis increased, with anterior uveitis being the most common subtype and significant ocular complications associated with intermediate and posterior uveitis. The study highlights the need for further prospective research to determine whether the rising rates reflect a true increase in disease incidence or improved detection methods.

Predictors of Vision Loss and Surgical Intervention in Stevens-Johnson Syndrome: A Multicenter Nationwide Cohort Study

Sep 18, 2026

The authors aimed to identify clinical predictors of surgical intervention and vision loss in patients with chronic Stevens-Johnson syndrome (SJS). Their multicenter study found that advanced disease presentations, such as limbal stem cell deficiency and conjunctivalization, were significant predictors for surgery, while factors like chronicity of the disease and the use of systemic therapies were associated with progressive vision loss. The findings highlight the importance of early referral and standardized care to improve patient outcomes.

Photography-based Retinal Vasculometry and Visual Field Progression in Primary Open Angle Glaucoma

Sep 18, 2026

The authors aimed to determine whether retinal vasculometry features derived from baseline fundus photographs are predictive of longitudinal visual field changes in glaucoma suspects and patients with primary open-angle glaucoma. Their analysis of 1,595 eyes revealed significant associations between specific vasculometry metrics, such as venous and arterial fractal dimensions and tortuosity, and the rate of visual field deterioration. These findings suggest that retinal vascular characteristics may serve as potential prognostic markers, warranting further validation for clinical application.

Ultra-Widefield OCT Mapping of Foveal and Optic Nerve Head Topography Within Posterior Staphyloma in Pathologic Myopia

Sep 17, 2026

The authors aimed to define the spatial relationship between the fovea and optic nerve head (ONH) in eyes with pathologic myopia and posterior staphyloma, and to evaluate their associations with foveal complications and peripapillary atrophy. Using ultra-widefield optical coherence tomography (UWF-OCT), they found that the fovea is more often located on the slope of the staphyloma, while ONH location is influenced by axial length, with longer eyes less likely to have the ONH at the staphyloma bottom. Additionally, peripapillary atrophy was associated with both ONH location and axial length, indicating distinct remodeling mechanisms in the macula and peripapillary region in pathologic myopia.

Regeneration and Replacement of the Corneal Endothelium: Advances in Cell Therapy, Tissue Engineering, Molecular and Pharmacologic Strategies

Sep 17, 2026

The authors aim to evaluate recent advancements in corneal endothelial cell therapy, tissue engineering, and pharmacologic strategies for the regeneration and replacement of the corneal endothelium, addressing the limitations of current endothelial keratoplasty due to donor tissue shortages. They compare various therapeutic modalities, including cultured donor-derived cell injections and emerging techniques like mitochondrial transfer and gene editing, based on their translational readiness and potential clinical applications. The review highlights the need for innovative, donor-independent approaches to improve treatment outcomes for corneal endothelial dysfunction.

Recurrence of Hypertropia in Sagging Eye Syndrome

Sep 16, 2026

The authors aimed to evaluate the surgical outcomes and recurrence rates of hypertropia in patients with sagging eye syndrome (SES) following strabismus surgery. Their findings revealed that while surgery initially corrected hypertropia, approximately 31% of patients experienced symptomatic recurrence after an average of two years, highlighting the progressive nature of SES. The study also noted that surgical overcorrections were rare and not significantly linked to the degree of preoperative hypertropia.

Impact of Botulinum Toxin on Ocular Surface Parameters in Patients with Orbicularis Spasm: A Systematic Review and Meta-Analysis

Sep 16, 2026

This systematic review and meta-analysis aimed to clarify the effects of botulinum toxin (BTX) on ocular surface parameters in patients with orbicularis spasm, specifically assessing outcomes related to tear film stability and ocular symptoms. The findings indicate that BTX significantly improves ocular surface disease index scores and tear break-up time, while having neutral effects on Schirmer tests and reducing astigmatism. The authors suggest that these improvements may be linked to reduced involuntary eyelid contractions rather than direct biological effects of BTX on ocular surface physiology, highlighting the need for further research to explore these mechanisms.

Visual performance of a refractive extended depth of field intraocular lens in monovision and emmetropic settings

Sep 12, 2026

The authors aimed to compare the visual performance, low-contrast visual acuity, stereopsis, and patient-reported outcomes of a refractive Extended Depth of Field intraocular lens (IOL) when implanted in either a mini-monovision or emmetropic setting. The study found that both strategies provided excellent distance and intermediate vision, but the emmetropic group exhibited better low-contrast visual acuity, while the mini-monovision group showed slightly increased glare and reduced near spectacle dependence. Overall, both approaches resulted in high patient satisfaction and preserved stereopsis.

ENDOTHELIAL KERATOPLASTY IN EYES WITH PREVIOUS GLAUCOMA SURGERY: A SYSTEMATIC REVIEW AND META-ANALYSIS STRATIFIED BY GRAFT TECHNIQUE

Sep 12, 2026

The authors aimed to evaluate graft survival, endothelial cell loss, and complication rates following endothelial keratoplasty (EK) in eyes with prior glaucoma surgery, comparing outcomes between Descemet stripping automated endothelial keratoplasty (DSAEK) and Descemet membrane endothelial keratoplasty (DMEK). Their systematic review and meta-analysis revealed that only 50% of eyes with prior glaucoma drainage device (GDD) implantation retained a functioning graft at 36 months, with DSAEK showing a numerical advantage in graft survival, particularly in GDD eyes. The study highlights the need for prospective registries with standardized endpoints to better guide clinical decision-making.