May 7, 2026 · American journal of ophthalmology · DOI: 10.1016/j.ajo.2026.04.032

Risk of non-infectious uveitis associated with disease-modifying therapies for multiple sclerosis

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The authors aimed to determine whether disease-modifying therapies (DMTs) for multiple sclerosis (MS) influence the risk of developing non-infectious uveitis (NIU). Their study found that certain DMT classes, particularly nucleic acid synthesis inhibitors/S1P modulators and fumarates, are associated with a reduced incidence of NIU compared to glatiramer acetate, suggesting potential for personalized MS treatment and repurposing these therapies for NIU in other populations.

Anthony J Cordisco, Fangming Jin, Ali G Hamedani, Brian L VanderBeek

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