April 30, 2026 · American journal of ophthalmology · DOI: 10.1016/j.ajo.2026.04.023

Association between retinal nerve fiber layer thickness and cardiovascular-kidney-metabolic syndrome: A UK Biobank cohort study

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The authors aimed to investigate the relationship between retinal nerve fiber layer (RNFL) thickness and the severity of cardiovascular-kidney-metabolic (CKM) syndrome in a large cohort from the UK Biobank. Their findings indicate that thinner RNFL is significantly associated with advanced stages of CKM syndrome, suggesting that RNFL thickness could serve as a potential marker for monitoring CKM syndrome severity. Further research is needed to explore the underlying mechanisms and validate RNFL as a prognostic indicator in larger populations.

Jihei Sara Lee, Seok-Jae Heo, David Myung, Chan Yun Kim, Sang Yeop Lee

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