August 3, 2026 · American journal of ophthalmology · DOI: 10.1016/j.ajo.2026.07.056

Refining How We Diagnose and Classify Limbal Stem Cell deficiency

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The authors aim to refine the diagnosis and classification of limbal stem cell deficiency (LSCD) by establishing a comprehensive algorithm that incorporates multimodal imaging and molecular diagnostic tests. They highlight the limitations of traditional methods, such as fluorescein staining, and advocate for a standardized approach that considers various ocular surface factors and comorbidities to enhance diagnostic accuracy and guide treatment strategies. Ultimately, this framework seeks to improve the management of LSCD and facilitate the development of new regenerative therapies.

Clemence Bonnet, Allan Slomovic, Friedrich Kruse, Sophie X Deng

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