July 30, 2026 · American journal of obstetrics and gynecology · DOI: 10.1016/j.ajog.2026.07.030

Antenatal magnesium sulfate prior to very preterm birth in routine care is associated with increased survival without cerebral palsy

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The authors aimed to evaluate the impact of antenatal magnesium sulfate on survival without cerebral palsy or moderate-severe functional impairment in extremely preterm and low birthweight infants. Their findings indicate that magnesium sulfate exposure is associated with a reduced risk of death and cerebral palsy, particularly in singleton pregnancies, suggesting significant benefits for this population and supporting its continued use in clinical practice.

Emily Shepherd, Alice Rumbold, Sarah McIntyre, Shona Goldsmith, Tasneem Karim, Amy Keir, Amanda Poprzeczny, Rod W Hunt, Nadia Badawi, Christopher J D McKinlay, Caroline A Crowther, Lisa N Yelland, Australian and New Zealand Neonatal Network, ANZNN

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