Impact of childhood and parental smoking and substance use on nephrotic syndrome outcomes: a prospective cohort study

The authors aimed to investigate the impact of childhood and parental smoking, alcohol, and recreational drug use on the outcomes of nephrotic syndrome in children. Analyzing data from a prospective cohort of 732 children, they found that while a small percentage reported substance use or exposure to household smoking, there were no significant associations between these exposures and nephrotic syndrome outcomes such as relapse rates, initiation of steroid-sparing medications, or hospitalizations. The study suggests that substance exposure does not clearly affect the longitudinal outcomes of nephrotic syndrome in this population.